SMART App User Guide

A step-by-step guide for clinicians using the SgTxGNN SMART application.

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Getting Started

Prerequisites

• Access to a SMART on FHIR enabled EHR system
• SgTxGNN app registered with your institution
• Valid user credentials for your EHR

Launching the App

1. From your EHR: Look for "SgTxGNN" or "Drug Repurposing" in your app launcher
2. Select a patient: The app requires patient context
3. Authorise: Grant the app permission to read medication data
4. View results: See repurposing predictions for patient medications

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Understanding the Interface

Patient Information Panel

Displays basic patient demographics loaded from the EHR:

• Patient name
• Date of birth
• Gender
• Patient ID

Current Medications

Lists all active medications for the patient:

• Medication name
• Status (active, completed, etc.)
• Has Insights badge indicates repurposing predictions available

Repurposing Insights

For medications with predictions:

• Indication: The predicted new use
• Source: Prediction method (KG, DL, or KG+DL)
• Evidence Level: L1-L5 classification

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Evidence Levels Explained

Level	Meaning	Clinical Relevance
L1	Multiple Phase 3 RCTs	Strong evidence, may support clinical use
L2	Single RCT or Phase 2	Moderate evidence, consider with caution
L3	Observational studies	Emerging evidence, needs validation
L4	Preclinical/mechanistic	Early research stage
L5	Model prediction only	Research hypothesis

Special Indicators

• KG+DL: Prediction validated by both Knowledge Graph AND Deep Learning methods - higher confidence
• High Score (>0.99): Very strong model confidence

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Best Practices

Do

• Use predictions as research starting points
• Verify findings with current literature
• Discuss with colleagues and pharmacists
• Consider patient-specific factors

Don't

• Make treatment decisions based solely on predictions
• Prescribe off-label without proper evaluation
• Ignore standard clinical guidelines
• Skip regulatory requirements

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Troubleshooting

App won't launch

1. Check your network connection
2. Ensure you have a patient selected
3. Verify app is registered with your EHR
4. Contact your IT support

No medications shown

1. Patient may have no active medications
2. Check patient has medication records in EHR
3. Verify app has permission to read MedicationRequest

No predictions available

Not all medications have repurposing predictions. The app only shows results for:

• HSA-approved medications
• Drugs mapped to DrugBank identifiers
• Drugs included in TxGNN knowledge graph

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Privacy & Security

• No data storage: Patient data is never stored by SgTxGNN
• In-browser processing: All analysis happens locally
• Encrypted connections: HTTPS only
• OAuth 2.0: Industry-standard authentication

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Disclaimer
SgTxGNN predictions are for research purposes only and do not constitute medical advice. Always follow clinical guidelines and consult with healthcare professionals before making treatment decisions.